CSTB team: Complex Systems and Translational Bioinformatics

Luc Moulinier

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• Research engineer CNRS, at ICube, UMR CNRS 7357.


My main activity is focused on the development of the ORDALIE software (Ordered Alignment Expert Information) dedicated to the analysis and exploitation, in real time, of the evolutionary and structural information in a multiple alignment of complete sequences. In this context, I am also working on a benchmark dedicated to the automated analysis and exploitation of sequence and structure data. I am also involved in the adaptation of the SM2PH database to create a knowledge base (SM2PH-KB for Knowledge Base) and the extension of this new base to new data types.

Other activities

  • Development of software and databases
  • Maintenance of software and databases
  • Development of strategies for the analysis and exploration of functional genomics data
  • Treatment of high-throughput data, including sequence and structure data in a context of complete genomes
  • Science and Technology Watch for the Tcl/Tk programming language and structural analysis software
  • Dissemination and exploitation of results through publications and conferences and training.


Schwenzer H, Scheper GC, Zorn N, Moulinier L, Gaudry A, Leize E, Martin F, Florentz C, Poch O, Sissler M. Released selective pressure on a structural domain gives new insights on the functional relaxation of mitochondrial aspartyl-tRNA synthetase. Biochimie. 2014 May;100:18-26.

Luu TD, Rusu A, Walter V, Linard B, Poidevin L, Ripp R, Moulinier L, Muller J, Raffelsberger W, Wicker N, Lecompte O, Thompson JD, Poch O, Nguyen H. KD4v: Comprehensible Knowledge Discovery System for Missense Variant. Nucleic Acids Res. 2012 Jul;40(Web Server issue):W71-5.

Luu TD, Rusu AM, Walter V, Ripp R, Moulinier L, Muller J, Toursel T, Thompson JD, Poch O, Nguyen H. MSV3d: database of human MisSense Variants mapped to 3D protein structure. Database (Oxford). 2012 Apr 3;2012:bas018.

Bard N, Bolze R, Caron E, Desprez F, Heymann M, Friedrich A, Moulinier L, Nguyen NH, Poch O, Toursel T. Décrypthon grid - grid resources dedicated to neuromuscular disorders. Stud Health Technol Inform. 2010;159:124-33.

Friedrich A, Garnier N, Gagnière N, Nguyen H, Albou LP, Biancalana V, Bettler E, Deléage G, Lecompte O, Muller J, Moras D, Mandel JL, Toursel T, Moulinier L, Poch O. SM2PH-db: an interactive system for the integrated analysis of phenotypic consequences of missense mutations in proteins involved in human genetic diseases. Hum Mutat. 2010 Feb;31(2):127-35.

Stoetzel C, Riehm S, Bennouna Greene V, Pelletier V, Vigneron J, Leheup B, Marion V, Hellé S, Danse JM, Thibault C, Moulinier L, Veillon F, Dollfus H. Confirmation of TFAP2A gene involvement in branchio-oculo-facial syndrome (BOFS) and report of temporal bone anomalies. Am J Med Genet A. 2009 Oct;149A(10):2141-6.

Raffelsberger W, Krause Y, Moulinier L, Kieffer D, Morand AL, Brino L, Poch O. RReportGenerator: automatic reports from routine statistical analysis using R. Bioinformatics. 2008 Jan 15;24(2):276-8.

Friedrich A, Ripp R, Garnier N, Bettler E, Deléage G, Poch O, Moulinier L. Blast sampling for structural and functional analyses. BMC Bioinformatics. 2007 Feb 23;8:62.

Albeck S, Alzari P, Andreini C, Banci L, Berry IM, Bertini I, Cambillau C, Canard B, Carter L, Cohen SX, Diprose JM, Dym O, Esnouf RM, Felder C, Ferron F, Guillemot F, Hamer R, Ben Jelloul M, Laskowski RA, Laurent T, Longhi S, Lopez R, Luchinat C, Malet H, Mochel T, Morris RJ, Moulinier L, Oinn T, Pajon A, Peleg Y, Perrakis A, Poch O, Prilusky J, Rachedi A, Ripp R, Rosato A, Silman I, Stuart DI, Sussman JL, Thierry JC, Thompson JD, Thornton JM, Unger T, Vaughan B, Vranken W, Watson JD, Whamond G, Henrick K. SPINE bioinformatics and data-management aspects of high-throughput structural biology. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1184-95.

Garnier N, Friedrich A, Bolze R, Bettler E, Moulinier L, Geourjon C, Thompson JD, Deléage G, Poch O. MAGOS: multiple alignment and modelling server. Bioinformatics. 2006 Sep 1;22(17):2164-5.

Plewniak F, Bianchetti L, Brelivet Y, Carles A, Chalmel F, Lecompte O, Mochel T, Moulinier L, Muller A, Muller J, Prigent V, Ripp R, Thierry JC, Thompson JD, Wicker N, Poch O. PipeAlign: A new toolkit for protein family analysis. Nucleic Acids Res. 2003 Jul 1;31(13):3829-32.

Moulinier L, Case DA, Simonson T. Reintroducing electrostatics into protein X-ray structure refinement: bulk solvent treated as a dielectric continuum. Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2094-103.

Moulinier L, Eiler S, Eriani G, Gangloff J, Thierry JC, Gabriel K, McClain WH, Moras D. The structure of an AspRS-tRNA(Asp) complex reveals a tRNA-dependent control mechanism. EMBO J. 2001 Sep 17;20(18):5290-301.

Billas IM, Moulinier L, Rochel N, Moras D. Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects. J Biol Chem. 2001 Mar 9;276(10):7465-74.

Frugier M, Moulinier L, Giegé R. A domain in the N-terminal extension of class IIb eukaryotic aminoacyl-tRNA synthetases is important for tRNA binding. EMBO J. 2000 May 15;19(10):2371-80.

Becker HD, Roy H, Moulinier L, Mazauric MH, Keith G, Kern D. Thermus thermophilus contains an eubacterial and an archaebacterial aspartyl-tRNA synthetase. Biochemistry. 2000 Mar 28;39(12):3216-30.

Eiler S, Dock-Bregeon A, Moulinier L, Thierry JC, Moras D. Synthesis of aspartyl-tRNA(Asp) in Escherichia coli--a snapshot of the second step. EMBO J. 1999 Nov 15;18(22):6532-41.

Locher KP, Rees B, Koebnik R, Mitschler A, Moulinier L, Rosenbusch JP, Moras D. Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. Cell. 1998 Dec 11;95(6):771-8.

Schmitt E, Moulinier L, Fujiwara S, Imanaka T, Thierry JC, Moras D. Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation. EMBO J. 1998 Sep 1;17(17):5227-37.

Organisation of conferences

  • Organising committee member, 13th European Conference Computational Biology (ECCB’14), Strasbourg 7-10/09/2014.


Dr. Luc Moulinier
ICube, UMR CNRS 7357
Faculté de Médecine
Bât. 3 5e étage,
11 rue Humann
F-67000 Strasbourg

Mailing address: Faculté de Médecine, ICube, UMR 7357, LBGI - 4, rue Kirschleger - F-67085 Strasbourg cedex

Email : luc.moulinier@unistra.fr